Landmannaleið, or the F225, is a highland road that leads to the Fjallabak Nature Reserve and towards Landmannalaugar, a region of rhyolite mountain, hot springs and hiking trails.
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This route is well-known for being much more adventurous than the standard routes into these areas; it crosses rivers, is surrounded by lunar landscapes, and is pretty bumpy. While a two-wheel-drive should never be taken down here, a super jeep can allow you to enjoy the journey safely.
Off-road driving is completely illegal in Iceland, but Landmannaleið is a road where this does not matter, due to its remoteness and uninterrupted surrounding nature.